As drugs kill tumor cells

As drugs kill tumor cells

A variety of mechanisms for the border combat cancer effect of the drug doxorubicin held responsible. This means an injury to the Erbmaterials the trigger of cell death of cancer cells through a kind of suicide programme, which is also known as apoptosis.

The exact mechanism by doxorubicin mediated cell death has not yet been sufficiently clarified. In one of the Wilhelm Sander Foundation-funded project is a research team led by Dr. Sandra Bien from the group of Prof. Heyo Kroemer (Department of Pharmacology) at the University of Greifswald by the mechanism of cancer cell death triggered doxorubicin resources. With the ever-improving treatment options for infectious diseases and cardiovascular diseases and a related increase in life expectancy cancer is the second leading cause of death worldwide. One of the most commonly used cancer drugs, doxorubicin, in the many different cancers that can be used successfully.

Despite a more than 30 years of use of doxorubicin against cancer, the mechanisms on which the effects of based, is still controversial. Presumed mechanisms include the installation of the substance in the genetic material with resulting damage and the formation of the cancer cell harmful oxygen compounds. In addition, it is known that doxorubicin directly processes in the cancer cell activates the cell to move a kind of "suicide" to celebrate. This process is known as programmed cell death or apoptosis. These are throughout life in the human organism process held, inter alia, for embryonic development, the balance of cell growth and cell destruction and the regulation of our immune system is of central importance. Apoptosis can be very different stimuli are triggered. These include various cancer therapeutics and UV radiation. Increasingly, a role of proteins called Cathepsin's family of apoptosis operations discussed. In particular, cathepsin B in the centre stage of cell death. This protein is also under the influence of doxorubicin in tumor cells increased.

It is also interesting the fact that there are approaches to therapy with doxorubicin connections that are under the influence of Cathepsin B in the cancer cell doxorubicin damaging split. Therefore, studies on the involvement of Cathepsin B on doxorubicin triggered by cell of particular interest and could contribute to the effect of doxorubicin in cancer cells better. Furthermore, the results obtained for optimizing a cancer therapy through the use of Cathepsin B-activated cancer therapeutics, and therefore possibly a certain selectivity to damage cancer cells explained.

One goal of the Wilhelm Sander Foundation funded research project is, therefore, the participation of Cathepsin B on doxorubicin-mediated cell death of cancer cells using specific and innovative methods, such as the selective off the protein Cathepsin B, and thus fosters knowledge about the mechanism of the specific effects of doxorubicin in cancer cells.

The Wilhelm-Sander Foundation supports this research project with more than 90,000 €.

Foundation purpose of the foundation is to medical research, especially projects in the framework of the fight against cancer. Since the founding of the Foundation were a total of 160 million euros for the promotion of research in Germany and Switzerland granted. The Foundation is from the estate of the same entrepreneur out in 1973 died.

Fit maker Fruit and Vegetables

Fit maker Fruit and Vegetables:

Five servings a day - so you go!
The more fruits and vegetables, the better for your health. Experts recommend at least five servings daily. How does it work in everyday life? Tips and recipes can be found here

Studies have shown who regularly greater quantities of fruit and vegetables eaten, reduces risk for cancer, diabetes, obesity or heart disease. Fruit and vegetables are rich in so-called secondary plant substances. The highly helpers to health in many ways. Known representatives are, for example, carotenoids in carrots, polyphenols in grapes, Sulfides in garlic, glucosinolates in cabbage or terpenes in citrus fruits.

To the best possible health effects, we should at least five daily servings of fruit and vegetables to eat. The nutrition experts recommend and leading health organizations like the American Society for Nutrition and the American Cancer Society. These are also members of the health campaign "5 a day", which is for a higher fruit and vegetable consumption committed.

It is also important for the varieties from to change. The more different secondary plant substances we take with us, the better the protective effect. But secondary plant substances are not the only maker Fit: Fruit and vegetables also provide valuable vitamins, minerals and fibre.

How much is a serving?

Five servings a day - that sounds complicated, but it is quite simple. Adults should daily total of about 600 grams of fruit and vegetables to eat, ideally to 3 servings of vegetables and 2 servings of fruit. That does not mean that the amount to five servings split. The decisive factors are the total of 600 grams. The practical measure of a serving is one's own hand: 5 servings = 5 times a "handful". Thus, each of the quantities it needs.

1 portion of fruit or vegetables is, for example:
-- 1 apple, 1 orange or 1 banana (1 handful of large, whole fruit)
-- 2 small hands full fruits such as berries, grapes
-- 1 handful of an crushed vegetables as 1 kohlrabi or fennel bulb, 1 large tomato
-- 2 hands full salad or crushed vegetables (Broccoli sprouts, Brussels sprouts)
-- 1 handful of dried legumes (lentils, beans)

A portion of fresh fruit, you can also times against 1 / 2 handful of (25 g) dried fruit exchange. In addition, a glass of fruit or vegetable juice - preferably freshly squeezed - one of the 5 servings replace. Also nuts in small quantities (1 / 2 handful of equivalent to about 25 g) may occasionally 1 portion cover.

Tips for every day

The first portion, you can easily with breakfast. Do you eat a cereal with 1 apple, 1 orange or 1 banana. Muesli muffel can also her favorite sandwich and enjoy a glass of orange juice supplement or 1 handful of fresh fruit to eat. Morning session covers a sandwich with 1 handful of Nibblers vegetables (carrot, cucumber slices, tomato) the second portion. You can lunch with crispy vegetables or salad again one to two servings. Simply doubling the portion of vegetables that you eat anyway. After lunch provides a further portion of fruit. Are you pure too boring, mix it with yogurt or curd. At night you have a salad, vegetable soup or a fresh Nibblers vegetables reached your target - without weighing and measuring. Do it simply, as much as possible to eat vegetables, as a supplement or main dish, but also as Nibblers raw vegetables or salad.

Make sure you have colorful variety. In winter, frozen vegetables also a valuable alternative to fresh vegetables. It is fine for quick vegetable dishes, soups, sauces and on raunds. Desserts such as milk or rice pancakes are great with fresh or frozen fruit operation.

Do something very quickly, are also ready meals. A lush occupied vegetable pizza or a vegetable dish from the freezer can also contributed to the daily ration vegetables.